av I Mäkeläinen · 2003 · Citerat av 2 — protection has contributed to the understanding of global transport processes in stratosphere radionuclide efflux and result in lower doses. In the long term,

Cyp8b1, och en ökning av efflux transportör Bsep, Mrp2 uttryck. Dessutom, Alisol B 23-acetat inducerade uttryck av STAT3 fosforylering, och STAT3 mål gener

Efflux transporter-expressing cells actively pump substrates out of the cell, which results in a lower rate of substrate accumulation, lower intracellular concentration at steady state, or a faster rate of substrate elimination from cells loaded with the substrate. A comprehensive in vitro ABC (efflux) transporter assay portfolio is available as contract research service. Ciprofloxacin is subject to efflux from J774 macrophages through a multidrug resistance-related protein-like transporter (J. M. Michot, F. Van Bambeke, M. P. Mingeot-Leclercq, and P. M. Tulkens, Antimicrob. Efflux transport proteins (transporters) provide a potential solution to facilitate the export of these products, mitigate toxic effects, and enhance production. P-gp is an efflux protein system associated with the ATP binding cassette (ABC) sub-family B membrane or Multi-drug resistance 1 (MDR1) or cluster of differentiation 243 which belong to ABCB (MDR) super family of ABC transporter [ 6 ]. A comprehensive in vitro ABC (efflux) transporter assay portfolio is available as contract research service.

Efflux transportör

Svensk definition. Gener för membrantransportproteiner som förmedlar resistens mot giftiga föreningar. Ett flertal superfamiljer av Niraparib som substrat för effluxtransportörer (P-gp, BCRP och MATE1/2). Niraparib är ett substrat för P-glykoprotein (P-gp) och BCRP (breast cancer resistance Transportör som sitter i barriären. En del av efflux-systemet, kastar bl.a.

2013-01-01 · ABC efflux transporters also function in conjunction with drug metabolizing enzymes to eliminate drugs and their metabolites. Molecular cloning of transporter genes delineates the involvement of multiple genes encoding subtypes with similar function with different tissue distribution and specificity towards drugs.

Parasiter som utvecklat resistens mot maskmedel (anthelmintika) är ett utbrett problem över hela världen. De preparat som används idag har funnits länge på marknaden och endast ett fåtal nya preparat finns under utveckling.

Genes, MDR. MDR-gener. Svensk definition. Gener för membrantransportproteiner som förmedlar resistens mot giftiga föreningar. Ett flertal superfamiljer av

The major efflux transporters of the ABC family include MDR1 (P-glycoprotein,P-gp, ABCB1), BCRP (ABCG2), and MRP2 (ABCC2). The ABC efflux transporter P-glycoprotein (Pgp) has been demonstrated as a key element of the BBB that can actively transport a huge variety of lipophilic drugs out of the brain capillary endothelial cells that form the BBB. P-gp is an efflux protein system associated with the ATP binding cassette (ABC) sub-family B membrane or Multi-drug resistance 1 (MDR1) or cluster of differentiation 243 which belong to ABCB (MDR) super family of ABC transporter [ 6 ]. Efflux transporter-expressing cells actively pump substrates out of the cell, which results in a lower rate of substrate accumulation, lower intracellular concentration at steady state, or a faster rate of substrate elimination from cells loaded with the substrate. A comprehensive in vitro ABC (efflux) transporter assay portfolio is available as contract research service. Ciprofloxacin is subject to efflux from J774 macrophages through a multidrug resistance-related protein-like transporter (J.

In fact, many drug interactions that are not easily explained by an effect on the cytochrome P450 (CYP) enzyme system can now be explained by their influence on influx and efflux cell membrane transporters.1,2,3,4 Often times these cell membrane 2014-07-18 Viele übersetzte Beispielsätze mit "efflux transporter" – Deutsch-Englisch Wörterbuch und Suchmaschine für Millionen von Deutsch-Übersetzungen. Clinical relavance of efflux transporters Conclusion References. Efflux transporters are positioned so as to encounter potentially harmful substances face-to-face — in important places like the intestine, the placenta, and the blood-brain and blood-testes barriers, making them an excellent first line of defense. Chemotherapeutic drugs are underutilized in lung cancer management due in part to serious adverse drug reactions (ADRs). Aim: With studies revealing an association between interindividual patient ADR variation and efflux transporter variants, we carried out a meta-analysis and systemic review, in order to highlight current knowledge regarding the strength of association between efflux Request PDF | On Jan 1, 2010, Carsten Uhd Nielsen and others published Efflux transporters | Find, read and cite all the research you need on ResearchGate OMICS International is currently managing more than 400 Open Access journals with quality peer review and copyediting process.
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•. transport protein. Engelska - Svenska exempel. transporter · transportör.

Traducciones en contexto de "efflux" en inglés-español de Reverso Context: The ABCA1 transporter is involved in the efflux of cholesterol and phospholipids to lipid-poor lipoproteins. Kurset har til formål at sætte den studerende i stand til at definere og klassificerer lægemiddelstoftransportører og beskrive deres rolle i at bestemme ADMET (Absorption, Distribution, Metabolisme, Excretion og Toksicitet) egenskaber for lægemiddelstoffer.
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membrane transport protein. •. transport protein. Engelska - Svenska exempel. transporter · transportör. allmän - eur-lex.europa.eu. i.17 transportör.

6 mar 2012 Kolesterol efflux är en specific process som regleras av ett antal intracellulära transportörer, såsom ATP-bindande kassett transportör proteiner drug efflux protein YajR 107. According to their in eller ut ur cellen har tilldelats ett specifik integralt membranprotein, en transportör, genom vilken den tillåts drug efflux protein YajR 107.